Issues
ON THE HORIZON
Dual TCR-Expressing T Cells in Cancer: How Single-Cell Technologies Enable New Investigation
INFECTIOUS DISEASE
Evidence for Aerosol Transfer of SARS-CoV-2–Specific Humoral Immunity
B Cell Chronic Lymphocytic Leukemia Development in Mice with Chronic Lung Exposure to Coccidioides Fungal Arthroconidia
CD8+ Regulatory T Cells Induced by Lipopolysaccharide Improve Mouse Endotoxin Shock
CLINICAL AND TRANSLATIONAL IMMUNOLOGY
The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties
SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties
EDITORIAL
Negative Data, Oh No What Should I Do? How Publication of Negative Data Removes Roadblocks to Productive Research from the Perspective of Scientists Who Perform the Experiments
-
Cover Image
Cover Image
On the cover: Immunohistochemistry for human IgG4 demonstrates penetration of the anti-CD39 Ab SRF617 into the tumor microenvironment in a mouse orthotopic pancreatic cancer model. Strong staining is seen in the stromal compartment in viable areas of SRF617-treated tumors (pictured). Isotype-treated tumors show no staining in viable areas. Warren, M. C., S. Matissek, M. Rausch, M. Panduro, R. J. Hall, A. Dulak, D. Brennan, S. D. Yekkirala, S. Koseoglu, R. Masia, Y. Yang, N. Reddy, R. Prenovitz, J. Strand, T. Zaidi, E. Devereaux, C. J. Foissac, J. Stagg, B. H. Lee, P. Holland, V. J. Palombella, and A. C. Lake. 2023. SRF617 is a potent inhibitor of CD39 with immunomodulatory and antitumor properties. ImmunoHorizons 7: 366–379.
- PDF Icon PDF LinkEditorial Board