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On the cover: Students in a Course-Based Undergraduate Research Experience (CURE) course used site-directed mutagenesis to analyze specific amino acids that they hypothesized would be critical for the NADase function of the Acinetobacter baumannii Toll/IL-1R (TIR) domain-containing protein AbTir. Results from the CURE support findings from previous structural studies that predict conformational changes in AbTir upon ligand binding. Vallejo-Schmidt, T., C. Palm, T. Obiorah, A. R. Koudjra, K. Schmidt, A. H. Scudder, E. Guzman-Cruz, L. P. Ingram, B. C. Erickson, V. Akingbehin, T. Riddick, S. Hamilton, T. Riaz, Z. Alexander, J. T. Anderson, C. Bader, P. H. Calkins, S. S. Chaudhry, H. Collins, M. Conteh, T. A. Dada, J. David, D. Fallah, R. De Leon, R. Duff, I. R. Eromosele, J. K. Jones, N. Keshmiri, M. A. Mercanti, J. Onwezi-Nwugwo, M. A. Ojo, E. R. Pascoe, A. M. Poteat, S. E. Price, D. Riedlbauer, L. T. A. Rolle, P. Shoemaker, A. Stefano, M. K. Sterling, S. Sultana, L. Toneygay, A. N. Williams, S. Nallar, J. E. Weldon, G. A. Snyder, and M. L. D. Snyder. 2024. Characterization of the structural requirements for the NADase activity of bacterial Toll/IL-1R domains in a course-based undergraduate research experience. Immunohorizons 8: 563–576.