Part I. I. Introduction. The data contained in this paper are collected from the histories of 621 cases of human protein sensitization observed during the past five years and summarized in the protocol herewith published.

We were stimulated to this work as the result of a personal experience of one of us in the fall of 1910 with the realities and the possibilities of the protein reaction in sensitized individuals,—both its immediate dangers as well as its ultimate beneficial effect.

While not all of the histories cover all of the points discussed throughout the paper, extreme care has been used in eliciting them and only definite and positive facts are included. Any error, therefore, and errors undoubtedly do exist, is due rather to a lack of knowledge on the part of the patient and would appear on the negative rather than on the positive side in our statistics.

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