By the application of perfusion methods, an opsonin or bacteriotropin can be demonstrated in antipneumococcic serum, so altering pneumococci as to cause their adhesion to the endothelial cells lining the hepatic capillaries.

This opsonin is operative with the liver capillaries in many hundred times the dilution necessary to cause agglutination of the pneumococci, but is practically inoperative with the extrahepatic capillaries.

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