Bone marrow cells from hydrocortisone-treated donor mice are immunocompetent by themselves after transfer with sheep erythrocyte antigens to irradiated syngeneic recipients. Such cell suspensions do not synergize with thymus. This indicates that such marrow, unlike normal marrow, contains both B and T lymphocytes. The immunocompetence of hydrocortisone-treated marrow is abolished by anti-θ serum and restored by thymus cells. These results are compatible with the sequestration of peripheral T lymphocytes in bone marrow after treatment with hydrocortisone.

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Copyright © 1972 by The American Association of Immunologists, Inc.
1972
The Williams & Wilkins Company
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