Defective immunopoiesis in young adult AKR mice has been shown to be genetically regulated. Transfer of identical numbers of cells from the same spleen cell suspension into x-irradiated young adult mice of the AKR and C3H strains, the F1 and F2 progeny of these two strains, and the progeny of the two F1 backcrosses has provided direct evidence that the regulation of immunocompetent cell proliferation is genetic in nature. Statistical tests indicate that the evidence for genetic differences is consistent with a single, apparently non-H-2, autosomal gene locus.

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