Nature of the Antigenic Complex Recognized by T Lymphocytes: V. Genetic Predisposition of Independent F₁ T Cell Subpopulations Responsive to Antigen-Pulsed Parental Macrophages¹

Nonimmune (2 × 13)F₁ guinea pig T lymphocytes initially stimulated with trinitrophenyl- (TNP) modified macrophages from one parental strain and then treated with bromodeoxyuridrine (BUdR) and light are unable to be primed subsequently with TNP-modified macrophages of the same parental strain. In contrast, these BUdR and light treated F₁ T cells can be primed with TNP-modified macrophages of the other parental strain. These results demonstrate that in a nonimmune F₁ animal two T cell subpopulations exist before priming that are genetically predisposed to respond to antigen associated with macrophages derived from one or the other parent.