Abstract
Rabbit 136 represented the first instance whereby more than two alleles for any immunoglobulin locus are detected phenotypically in a single animal. This was reported as the acquisition of the a2 and b6 markers in the animal nominally typed a1a3, b4b5 after intensive immunization. Follow-up studies indicate that another immunoglobulin marker, notably d11, also appeared in the postimmune serum. The d11 specificity was detected serologically by the hemagglutination-inhibition assay and chemically by analysis of the CNBr digestion products involving a strategic methionine.
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Copyright © 1978 by The American Association of Immunologists, Inc.
1978
The Williams & Wilkins Company
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