Structural Studies on Protein Products of Murine Chromosome 17: III. Partial Amino Acid Sequence of an H-2K^Q Molecule¹

Twenty-one of the amino terminal twenty-seven amino acid residues have been assigned in the murine H-2K^q molecule and several additional assignments and corrections have been made in both the H-2K^k and H-2K^b molecules. The study shows that 1) H-2K^k and H-K^q, which are serologically related, have an identical amino acid sequence for all twenty positions that can be compared, 2) the H-2K^k and H-2K^q molecules differ from H-2K^b at only two positions-9 and 22, and 3) the additional sequence data on the H-2K^k, -K^b, and -K^q molecules increases the already striking homology between murine and human transplantation antigens.