The concept of adaptive differentiation predicts that early differentiation of lymphocytes can be conditioned by the environment in which such differentiation takes place such that the capacity for most effective cell-cell interactions between such lymphocytes, which is controlled by major histocompatibility complex-linked genes, is learned in the process of such differentiation. In these studies, we have tested the capacities of both helper T lymphocytes and hapten-primed B lymphocytes primed in the environments of all combinations of bone marrow chimeras prepared between two parental strains (i.e. A/J and BALB/c) and their corresponding F1 hybrid (CAF1) to interact with cooperating B or T cells derived from conventional parental and F1 donors as well as all of the corresponding bone marrow chimera combinations.

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