We have compared the serum alloantibody population from female rats immunized either by allogeneic pregnancies or by conventional immunizations. The only allogeneic difference in both types of immunization was class I of the MHC. Pregnancy-induced alloantibodies as compared with conventionally raised alloantibodies were more homogeneous with respect to isoelectric point, and were more homogeneous as defined by competition experiments with anti-class I monoclonal antibodies. The genetic control of the pregnancy-induced alloantibody response was also verified.

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