Response to Comment on “IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells”

My colleagues and I appreciate the feedback of Prof. Kang regarding Weiss et al. (1). Dr. Kang suggests that a hyperbolic equation would lead to a better fit than a sigmoid curve for the data in figure 1D. With either analysis, the correlation between IL-1β and IL-26 is still evident. My colleagues and I agree that the TLR8 data are outliers, but did not comment on that, as the mechanism for this is not clear. In addition to TLR8 being an endosomal receptor as Prof. Kang points out, work in our laboratory and others has revealed that TLR8 activation of PBMCs leads to distinct patterns of gene expression and cytokine secretion (2).