Memory CD4 T Cell Distribution and Recall Function in Nonlymphoid Organs

This Pillars of Immunology article is a commentary on the following two seminal articles: “Visualizing the generation of memory CD4 T cells in the whole body,” an article written by R. L. Reinhardt, A. Khoruts, R. Merica, T. Zell, and M. K. Jenkins, and published in Nature, in 2001. https://www.nature.com/articles/35065111, and “Protection from respiratory virus infections can be mediated by memory CD4 T cells that persist in the lungs,” by R. J. Hogan, W. Zhong, E. J. Usherwood, T. Cookenham, A. D. Roberts, and D. L. Woodland, and published in the Journal of Experimental Medicine, in 2001. https://doi.org/10.1084/jem.193.8.981.