Cloning of IL-12, a Critical Advance in Th1 and Th17 Discovery

This Pillars of Immunology article is a commentary on “Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells,” a pivotal article written by S. F. Wolf, P. A. Temple, M. Kobayashi, D. Young, M. Dicig, L. Lowe, R. Dzialo, L. Fitz, C. Ferenz, R. M. Hewick, et al., and published in The Journal of Immunology, in 1991. https://doi.org/10.4049/jimmunol.146.9.3074.