Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor controlling Treg cell differentiation and function. In this article, we review the current mechanistic and systemic understanding of Foxp3 function enabled by experimental and computational advances in high-throughput genomics.

Copyright © 2023 by The American Association of Immunologists, Inc.
2023
Copyright © 2023 by The American Association of Immunologists, Inc.
You do not currently have access to this content.