This Pillars of Immunology article is a commentary on “HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease,” a pivotal article written by G. Pantaleo, C. Graziosi, J. F. Demarest, L. Butini, M. Montroni, C. H. Fox, J. M. Orenstein, D. P. Kotler, and A. S. Fauci, and published in Nature, in 1993. The Journal of Immunology, 2023, 210: 1181–1182

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