This Pillars of Immunology article is a commentary on “Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones,” a pivotal article written by P. Salgame, J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom, and published in Science, in 1991.

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