PD-1–Targeted Immunotherapy: The Ligand Matters

This Pillars of Immunology article is a commentary on “PD-L2 is a second ligand for PD-1 and inhibits T cell activation,” a pivotal article written by Y. Latchman, C. R. Wood, T. Chernova, D. Chaudhary, M. Borde, I. Chernova, Y. Iwai, A. J. Long, J. A. Brown, R. Nunes, E. A. Greenfield, K. Bourque, V. A. Boussiotis, L. L. Carter, B. M. Carreno, N. Malenkovich, H. Nishimura, T. Okazaki, T. Honjo, A. H. Sharpe, and G. J. Freeman, and published in Nature Immunology, in 2001. https://www.nature.com/articles/ni0301_261.