The complement fixation reaction for tuberculosis has occupied the attention of many investigators for the past seventeen years,and it has been studied mainly from the standpoint of its possible value to clinical medicine in the diagnosis and prognosis of this disease. The methods commonly employed for diagnosing tuberculosis leave much to be desired and there is little doubt that many cases escape detection until marked damage has been done. A test, therefore, that will give a sure and early diagnosis,is of the utmost value both to the patient and to the general public.

The results of the early work with this complement fixation test were of such a contradictory nature that they were of little practical value. However, the reports of recent investigators seem to promise that this test will be of marked value to the clinician.

The following is a brief review of some of the more important investigations made during the past few years.

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