1. Vitamin C, when added to tetanus toxin in vitro, brings about inactivation of the toxin.

  2. This inactivation is not due to an acid effect, since it occurs when the ascorbic acid has been adjusted to a pH at which the potency of the toxin is undiminished.

  3. The inactivation phenomenon does not follow the laws of multiple proportions. Its chemical basis is obscure.

  4. Vitamin C fails to confer complete protection against tetanus intoxication in vivo, under the conditions of our tests.

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