From time to time, within recent years, the use of autogenous B. coli vaccines has been advocated as a therapeutic measure in the treatment of such conditions as chronic intestinal toxaemia (1) and eczema (2) on the assumption that the toxic substances giving rise to these conditions are produced through the activities of certain B. coli vegetating in the intestinal tract, and that these strains may be suppressed or eliminated through specific immunization. Apparently, however, this mode of treatment has not been substantiated by any experimental evidence either that the B. coli of the intestinal tract may be controlled through specific therapy or, if particular strains are reduced in numbers through this procedure, that the effect obtained is more than transitory. The study reported here was undertaken with the hope of throwing some light upon these points.

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