Studies in Human Malaria¹: IV. An Attempt at Vaccination of Volunteers Against Mosquito-Borne Infection with Pl. Vivax

Formalinized malaria vaccine, administered to man in relatively large quantity by various parenteral routes apparently was without serious toxicity. Local inflammatory reactions, chills and fever subsided with repeated administration.

The administration of such vaccine in a dosage of 10 billion formalinized parasites per man over a period of 13–14 days had no effect on susceptibility to infection with malaria by the bite of vivax-infected mosquitoes.