The sera from rabbits which had received repeated injections of catalase prepared from calf liver, when mixed with the homologous antigen, gave a precipitate which carried with it catalase from the solution, in amounts dependent on the quantities of sera used. There was no evidence that a true inhibitory antibody was present in the sera of the injected animals, since the precipitate was as active as the antigen in the liberation of oxygen from neutral H2O2. The theoretical aspects of the results are discussed.

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