A previous publication (1) described quantitative serial fecal virus isolations from familial associates of reported cases of poliomyelitis and demonstrated that most subclinical infections present at the time of gamma globulin inoculation were not eliminated nor was the amount of fecal virus reduced. The serological data presented in this report show that active immunization by subclinical infection is not inhibited by the administration of gamma globulin.

Neutralization tests with paired sera from 15 of 23 individuals with subclinical infection demonstrated significant increases in antibody titer to the specific immunological type of virus with which they were infected. The remaining eight had high levels of specific neutralizing antibody in the first sera with no subsequent elevations in titers.

Twenty-seven of thirty-two familial associates who remained uninfected already had specific neutralizing antibodies to the type of virus isolated from their respective family groups. These findings are in accord with previous observations which suggested that virus is less likely to become established in persons in whom antibodies are present prior to exposure.

Uninfected volunteers were inoculated with gamma globulin of known potency, and low levels of antibody were detected after three days to one week and persisted for only two to three weeks. These results eliminate the possible role of residual passive antibody on the titers obtained with sera collected six to eight weeks after gamma globulin administration to familial associates of poliomyelitis cases.

Pharyngeal virus isolations were successful in 6 of 25 individuals who had demonstrable alimentary infection. In all cases, the immunological types of the viruses from stool and pharyngeal secretions were identical. No viruses were isolated from sera nor from stools six months after their intestinal infection.

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