Relationship of the Anaphylaxis Sensitizing and Adjuvant Properties of Hemophilus Pertussis Vaccine¹

Pertussis vaccine administered along with chicken red blood cells (CRBC) in mice enhances the production of agglutinins to CRBC and also induces anaphylactic sensitivity to subsequent challenge doses of CRBC. However, the data presented indicate that serum agglutinins have little to do with mouse anaphylaxis. Pertussis vaccine stimulates the production of agglutinins to CRBC only if the CRBC are administered at the same time and via the same route as the pertussis vaccine. These conditions, however, are not necessary for the production of anaphylactic sensitivity.