The results of the experiments described indicate that comparable titers of specific circulating antibodies are induced following inoculation of identical quantities of soluble antigen either intracorneally or intravitreously. These titers, in turn, are comparable with those induced when the same quantity of antigen is incorporated in adjuvant and injected intramuscularly. These three methods of antibody induction have in common two basic mechanisms: a) slow diffusion of antigen from the site of inoculation and, b) the infiltration of the inoculation site with cells involved in the production of antibody. The use of avascular ocular routes in experimental immunization schedules in animals is suggested if antigen is scarce or if the use of an adjuvant is not desired.

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