Unresponsiveness to a purified protein was produced by intraperitoneal inoculation of antigen into guinea pigs in utero. This unresponsiveness embraced not only circulating antibody but also the delayed type of skin hypersensitivity. Unresponsiveness to a protein, such as hen egg albumin, conferred concomitant unresponsiveness to the same protein altered only by the addition of haptenic groups such as para-aminobenzoic acid. This unresponsiveness to the conjugate was demonstrated by the absence not only of detectable circulating antibody but also of detectable intracutaneous delayed hypersensitivity.

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