Summary
Pseudomonas pseudomallei and Pseudomonas aeruginosa, killed and dried, can replace the killed mycobacteria of complete Freund's adjuvants in the production of experimental allergic encephalomyelitis (EAE) in the guinea pig. Homologous guinea pig spinal cord is the source of the encephalitogenic “antigen” or “hapten.” The disease produced is milder than that produced when mycobacteria are used.
P. pseudomallei organisms are also effective mycobacterial substitutes when used with whole bovine spinal cord or lipid extract thereof.
Heterologous spinal cord, in this case bovine spinal cord, can cause mild central nervous system lesions of EAE even with incomplete Freund's adjuvants.
This content is only available via PDF.
Copyright © 1963 by The American Association of Immunologists, Inc.
The Williams & Wilkins Company
You do not currently have access to this content.