Allergic encephalomyelitis (AE) is suppressed in rats given whole body x-irradiation prior to sensitization with spinal cord plus adjuvant. Suppression of the disease is paralleled by reduced production of complement-fixing antibrain antibodies. There is little, if any, suppression of delayed-type immunologic reactivity, based on tuberculin skin testing. X-irradiation after sensitization does not suppress AE. The meaning of these findings with respect to pathogenesis of AE is discussed.

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