The majority of the skin reactions in rabbits immunized with a variety of synthetic polypeptide antigens which elicited the production of circulating antibody were the classical active Arthus reactions (Arthus type I). However, the polypeptide preparation Glu56Lys43Tyr1-1 elicited a skin reaction which followed the course of the delayed, or tuberculin, reaction despite the fact that it elicited the production of circulating antibody (Arthus type II). On the basis of the skin reactions elicited by the various synthetic polypeptides, the hypothesis was advanced that the character and intensity of the skin reactions are determined in part by the amino acid composition of the antigen.

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