Methotrexate Inhibition of Tuberculin Hypersensitivity in Inbred Guinea Pigs

Methotrexate has been employed to inhibit the development of tuberculin hypersensitivity in strain 2 guinea pigs. Tuberculin hypersensitivity is transferred in these animals with viable isologous lymph node cells. The results of experiments employing such lymph node transfers suggested the drug was not acting on the inductive phase of the immune response but on the proliferation of immunologically active cells.