1. Proflavine sharply alters the processes of transport of S-antigen of Sendai virus from the nucleolus to the cytoplasm, but does not essentially decrease its synthesis. The decrease in synthesis of the V-antigen is proportionately more marked.

  2. Retention of S-antigen in the nucleolus leads to the formation of incomplete virus and to a reduction of release of infectious virus from the cell.

  3. Interaction of proflavine with the viral RNA does not essentially alter the messenger mechanism responsible for synthesis of protein components of the virus.

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