Adenovirus particles agglutinate in the presence of optimal proportions of type-specific antisera. Reactions can be visualized either by electron microscopy or, if virus concentrations are sufficiently high, in test tubes with the unaided eye. Virus-antibody complexes are characteristically leaf-like, and are usually composed of only one layer of particles. The width of the fringe (probably antibody molecules) surrounding particles after reaction with antiserum averaged 33 mµ. Agglutination cross-reactions occur between adenovirus types 12 and 18, but other adenoviruses tested (types 1, 2, 3 and 7) agglutinate only with their own antiserum.

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