Unlike guinea pigs and man, mice injected with minute quantities of purified protein antigen under conditions especially favoring induction of delayed hypersensitivity developed immediate hypersensitivity more readily than delayed hypersensitivity. In these mice immediate hypersensitivity appeared first, developed more frequently, lasted longer and could be induced with less antigenic stimulus than was needed to induce delayed hypersensitivity. No early (“Jones-Mote”) form of delayed hypersensitivity was evident in these mice. Our results suggest that delayed hypersensitivity is not a necessary precursor of immediate hypersensitivity, and that mice differ from guinea pigs and man in the quality and timing of immunologic response to protein antigens.

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