Beryllium, a known granuloma-producing agent in man, has been substituted for mycobacteria in Freund's adjuvant and its effects on antibody production and delayed hypersensitivity to bovine serum albumin have been observed in rabbits and guinea pigs.

Animals inoculated with beryllium adjuvant emulsions exhibited only a moderate increase in antibody production to the antigen when compared with a control group given bovine serum albumin (BSA) in incomplete Freund's adjuvant. However, they developed virtually no delayed hypersensitivity to BSA when compared to a third group given BSA in complete Freund's adjuvant (with mycobacteria).

Histologic study showed marked similarities in the cellular response of the local injection sites of beryllium and mycobacterial adjuvants. However, the granulomata associated with beryllium were not as extensively disseminated or as rich in epithelioid cells as those associated with mycobacterial adjuvants.

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