The same spleen from chickens immunized in vivo and cultured in two types of media produced cells with different morphology. Those cultured in normal chicken serum had cells with the appearance of macrophages, large and small lymphocytes, plasma cells and monocytes. Cultures of the same spleen in egg white contained small cells with the appearance of either small lymphocytes or small plasma cells. The major immunoglobulin containing antibody in the chicken serum cultures and egg white cultures appeared to differ when studied by autoradiographic immunoelectrophoresis.

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