The effects on the blood group specificity of lima bean anti-A of coupling to it diazotized amino derivatives of D-glucose and D-galactose were investigated. The galactose derivatives all enhanced the anti-B activity, p-aminophenyl-α-N-acetyl-D-galactosaminide (Ga III) being the most effective. Some of the glucose derivatives also enhanced the anti-B activity, but tended more to confer also an anti-O activity. The anti-B activity of these modified lectins was inhibited by 1 M d-galactose, and all activity inhibited by N - acetyl - d - galactosamine. Possible chemical mechanisms of the observed changes are discussed.

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