During experimental Listeria infection in mice an increase in total serum protein, serum hexose and hexose: protein ratio was observed. Paper electrophoretic studies showed an increase in α- and β-glycoproteins. Immunoelectrophoretic studies on serum from infected animals revealed an increase in albumin mobility, increase in α2-macroglobulin, increase in haptoglobin, increase in transferrin and conversion of β1C-globulin to β1D-globulin. Relatively little change was noted in γ-globulin during infection. Hyperimmunized-challenged animals showed an increase in amount and complexity of γ-globulin.

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