In rabbits sensitized with BSA, high doses of chloramphenicol decreased the primary response but the secondary response, initiated 40 days later, was unaffected.

6-MP at the dose of 6 mg/kg/day suppressed completely the primary response; the secondary response was either strongly decreased or suppressed. Doses of 3 and 1 mg/kg/day had similar but weaker effects on primary response, whereas secondary response was almost normal.

Combination of different doses of chloramphenicol and 6-MP resulted in stronger effects on primary response than those obtained with the same doses of each drug used separately. In addition, a fair number of animals acquired immunologic tolerance which was specific to BSA, as proved by further injections of BSA and the use of a second antigen, HGG.

No synergistic effect was however observed on the survival of skin allografts in rabbits.

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