The adjuvant action of bacterial endotoxin on antibody production was shown to be unrelated to the effect of endotoxin on the thymus. Rates of antigen elimination and hemagglutination titers were essentially the same in adult mice which were thymectomized or sham-thymectomized and given a single injection of bovine γ-globulin and endotoxin. Reduction in antibody production was observed, however, when mice were thymectomized at 2 weeks of age.

Similarly, the response of adult mice to two injections of bovine γ-globulin and endotoxin was the same in thymectomized and sham-thymectomized mice. The antibody sedimented in a sucrose density gradient in the area of 7 S γ-globulin.

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