Adoptive transfer of a primary agglutinin response to sheep erythrocytes by spleen cells given to cyclophosphamide pretreated mice was studied. Various syngeneic, parent-to-hybrid and allogeneic donor-host combinations were investigated.

A linear log2 relationship between the agglutinin titer measured 5 days after transfer and the dose of nucleated cells injected existed for all the combinations studied. The slopes of the regression lines obtained with the various donor-host combinations were independent of the type of transfer, but the altitudes differed. In general, the magnitude of the agglutinin response was greater in allogeneic or parent-to-hybrid transfers than in the two possible syngeneic transfers represented by each donor-host pair.

Possible reasons for this “allogeneic enhancement” are considered.

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