Neonatally thymectomized A mice, grafted at 3 weeks with 3-week-old isogenic thymus or injected with 100 × 106 thymus cells, showed a nearly normal ability to reject CBA and C57B1/Ks skin grafts, which differ from A by a strong histocompatibility gene. When grafted with thymus or injected with thymus cells from mice tolerant to CBA, they showed a specific inability to reject CBA skin. On the basis of control experiments, it appeared that these animals had adoptive tolerance conveyed by the tolerant thymus cells and depending on thymus chimerism.

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