The primary antibody response to S. adelaide has been studied in mice using a flagellar immobilization assay. The change in spleen weight is bimodal with time: the first peak occurring on day 4 of the response and the second on day 10. Spleen homogenate supernatants also exhibit two distinct antibody peaks, but there is no direct correlation between the size of a spleen and its antibody content.

The primary antibody response consists of the early, transient production of γM antibodies followed by the production of γG antibodies. This response is quantitatively reduced by the removal of spleens from mice before antigen injection. Splenectomy does not, however, alter the proportion of γM to γG as compared to intact mice.

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