DNP-PLL genetic “non-responder” guinea pigs made tolerant to BSA by a low dose method exhibit a reduced synthesis of anti-DNP antibody upon immunization with DNP-PLL complexed electrostatically to BSA. The anti-DNP antibody synthesized by such animals is of low affinity as compared with that synthesized by normal “non-responder” guinea pigs.

1

This study was supported by United States Public Health Service Grants AI-2094 and AM-08805. Computer facilities of the Section on Communication Sciences, Department of Neurosurgery, New York University Medical Center made use of in this study were supported by United States Public Health Service Research Grant FR-00331-01A1.

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Copyright © 1969 by The American Association of Immunologists, Inc.
1969
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