Abstract
Immune tolerance was induced in guinea pigs to pentadecylcatechol and to cyclohexylmethylcatechol when oil solutions were injected subcutaneously. Structural features of these molecules associated with the induction and specificity of delayed contact sensitivity were operative in the induction and specificity of immune tolerance. These factors include the size and shape of the hydrocarbon side-chain which determine specificity, the presence of unsubstituted ring hydroxyl groups that permit quinone formation, and the availability of ring positions to permit coupling. Serum antibody could be found only occasionally either in sensitive or tolerant animals.
Footnotes
This work was carried out with the assistance of United States Government Contract PH-43-64-76 with the Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014.
