Rabbits inoculated intravenously with a single high dose of purified papovavirus SV40 synthesized antibodies to tumor or T antigen. The antibody activity against the T antigen was associated with 19S and 7S immunoglobulins. These rabbits also synthesized antibodies to viral structural antigens. However, the rabbits inoculated with a low dose of virus synthesized antibodies to viral structural antigen only. Restimulation of rabbits producing only antibody to viral antigens failed to induce the synthesis of T antibody.

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This work was supported in part by Research Grant CA-04600 from the National Cancer Institute, National Institutes of Health.

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Copyright, 1970, by The Williams & Wilkins Company
Copyright © 1970 by The American Association of Immunologists, Inc.
1970
The Williams & Wilkins Company