Abstract
Delayed sensitivity to the azobenzenearsonate (ABA) group in guinea pigs and rats may be suppressed by prior injection of ABA but not azobenzenephosphonate (ABP) conjugates. On the other hand, delayed sensitivity to the ABP group may be suppressed by both kinds of conjugate. This type of cross-reactivity between ABA and ABP groups is similar for reaction with antibody, delayed sensitivity and tolerance induction, thus indicating a similar recognition receptor for each process. The results suggest that in all these processes the binding site that recognizes the phosphanilate group is directed to the doubly-ionized, highly hydrated form, whereas that for the arsanilate group is specific for the singly ionized, less hydrated form. Suppression is more readily achieved by conjugates of polytyrosine than by conjugates of bovine serum albumin, which is probably indicative of the greater number of ABA and ABP-tyrosine determinants formed in the former relative to the latter type of carrier.
Footnotes
This work was supported by United States Public Health Service Grant AI-01289 and Training Grant AI-00022.
