Mast cells collected from certain mouse strains (e.g., A, C57BL) were shown to be significantly less susceptible than those collected from other strains (e.g., C3H, DBA/2) to in vitro passive anaphylactic sensitization by purified anti-hapten antibodies. Antibodies of isologous, homologous and heterologous (rat) origin were used with identical results. No relation between the presence or absence of a complement component (MuB1 Ag, C5) and susceptibility to sensitization was found, and no clear pattern of inheritance of this characteristic could be demonstrated.

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This work was supported by National Institutes of Health Grant AI-03075-10 and by the Health Research Council, City of New York, under Contract I-140.

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Copyright, 1970, by The Williams & Wilkins Company
Copyright © 1970 by The American Association of Immunologists, Inc.
1970
The Williams & Wilkins Company