Abstract
Sheep red blood cells sensitized with pneumococcal polysaccharide type III (SIII) react specifically with anti-SIII, and upon addition of complement are hemolyzed. This reaction provided the base for a hemolytic plaque procedure that was used to investigate the cellular response of mice to SIII given in amounts that induce either immunity or paralysis. Young offspring of immunologically paralyzed and normal mice showed differences in their response to SIII.
Footnotes
This investigation was supported by Contracts Nonr-1834(37) with the Office of Naval Research, United States Department of the Navy, and COO-1628-11 with the United States Atomic Energy Commission, and by Training Grant 2E-178, National Institute of Allergy and Infectious Diseases, United States Public Health Service.
