Guinea pigs fed a single large dose of picryl chloride after prior starvation are unresponsive to subsequent immunization with the hapten. The induction of tolerance by the single feeding technique is directly comparable to the state produced by multiple feedings in terms of dose, specificity and degree of resistance to contact and anaphylactic sensitization.

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This work was aided by General Support Grant FRO 5410-07 from the National Institutes of Health, Division of Research Facilities and Resources, and Grant AI 08455-01 from the National Institute of Allergy and Infectious Diseases.

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